48. Development of Antiplasmodial Peptide–Drug Conjugates Using a Human Protein-Derived Cell-Penetrating Peptide with Selectivity for Infected Cells

I. R. Palombi, N. Lawrence, A. M. White, C. L. Gare, D. J. Craik, B. J. McMorran, L. R. Malins, Bioconjugate Chem. 2023, doi: 10.1021/acs.bioconjchem.3c00147

47. Fine-Tuning Electroauxiliary-Mediated Peptide Modifications Using Second-Generation Electroactive Amino Acids

D. Karipal Padinjare Veedu, L. A. Connal, L. R. Malins, Org. Lett. 2023, doi: 10.1021/acs.orglett.3c00988

46. Amino Acid Sulfinate Salts as Alkyl Radical Precursors

J. M. Hammond, M. G. Gardiner, L. R. Malins, Org. Lett. 2023, doi: 10.1021/acs.orglett.3c01112

45. Tunable Electrochemical Peptide Modifications: Unlocking New Levels of Orthogonality for Side-Chain Functionalization

D. Karipal Padinjare Veedu, L. A. Connal, L. R. Malins, Angew. Chem. Int. Ed. 2022, doi: 10.1002/anie.202215470

44. Accessing Diverse Cross-Benzoin and α‐Siloxy Ketone Products via Acyl Substitution Chemistry

C. N. Larcombe, L. R. Malins, J. Org. Chem. 2022, doi: 10.1021/acs.joc.2c00801

[Featured on Organic Chemistry Portal]

43. Peptide Macrocyclisation via Late-Stage Reductive Amination

H. J. Bell, L. R. Malins, Org. Biomol. Chem. 2022, doi: 10.1039/D2OB00782G

[Featured in Org. Chem. Highlights]

42. Synthesis of Amino Acid α-Thioethers and Late-Stage Incorporation into Peptides

K. D. Milewska, L. R. Malins, Org. Lett. 2022, doi: 10.1021/acs.orglett.2c01297

41. Synthesis of Peptide N-Acylpyrroles via Anodically Generated N,O-Acetals

Y. Lin, L. R. Malins, Synthesis 2022, doi: 10.1055/s-0041-1737411

40. Umpolung Strategies for the Functionalization of Peptides and Proteins

A. M. White, I. R. Palombi, L. R. Malins, Chem. Sci. 2022, doi: 10.1039/D1SC06133J

39. Investigating Bicyclobutane–Triazolinedione Cycloadditions as a Tool for Peptide Modification

B. D. Schwartz, A. P. Smyth, P. E. Nashar, M. G. Gardiner, L. R. Malins, Org. Lett. 2022, doi: 10.1021/acs.orglett.1c04071

38. Electrochemistry for the Chemoselective Modification of Peptides and Proteins

A. S. Mackay, R. J. Payne, L. R. Malins, J. Am. Chem. Soc. 2021, doi: 10.1021/jacs.1c11185

37. Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates

M. Ayurini, P. G. Chandler, P. D. O’Leary, R. Wang, D. Rudd, K. D. Milewska, L. R. Malins, A M. Buckle, J. F. Hooper, JACS Au 2021, doi: 10.1021/jacsau.1c00453

36. Organometallic Reagents Primed for Peptide Modification

C. Elgindy, L. R. Malins, Chem Catalysis 2021, 1, 758–760. [Preview Article]

35. An Electrochemical Approach to Designer Peptide α-Amides Inspired by α-Amidating Monooxygenase Enzymes

Y. Lin, L. R. Malins, J. Am. Chem. Soc. 2021, doi: 10.1021/jacs.1c05718

34. A Rapid and Mild Sulfation Strategy Reveals Conformational Preferences in Therapeutically Relevant Sulfated Xylooligosaccharides

Y. Vo, B. D. Schwartz, H. Onagi, J. S. Ward, M. G. Gardiner, M. G. Banwell, K. Nelms, L. R. Malins, Chem. Eur. J. 2021, doi: 10.1002/chem.202100527 

33. Total Synthesis of Biseokeaniamides A-C and Late-Stage Electrochemically-Enabled Peptide Analogue Synthesis


Y. Lin, L. R. Malins, Chem. Sci. 202011, 10752–10758.

32. Structurally Diverse Acyl Bicyclobutanes: Valuable Strained Electrophiles


B. D. Schwartz, M. Y. Zhang, R. H. Attard, M. G. Gardiner, L. R. Malins, Chem. Eur. J. 2020, 26, 2808–2812.

31. Late-Stage Functionalization of Histidine in Unprotected Peptides

LSF histidine abstract

A. F. M. Noisier, M. J. Johansson, L. Knerr, M. A. Hayes, W. J. Drury III, E. Valeur, L. R. Malins, R. Gopalakrishnan, Angew. Chem. Int. Ed. 2019, 58, 19096–19102.

30. Total Synthesis of Suillusin

Suillusin graphical abstract

M. Y. Zhang, L. R. Malins, J. S. Ward, R. A. Barrow, Org. Lett. 2018, 20, 7304–7307.

29. Hitting the Sweet Spot

Nature Chemistry News & Views Highlight

L. R. Malins, Nature Chem. 201810, 578–580.

28. Peptide Modification and Cyclization via Transition-Metal Catalysis

Current opinion_graphical abstract submission_final (1)

L. R. Malins, Curr. Opin. Chem. Biol. 2018, 46, 25–32.

27. Decarboxylative Couplings as Versatile Tools for Late-Stage Peptide ModificationsPeptide Science Review abstract for website

L. R. Malins, Peptide Science2018, doi: 10.1002/pep2.24049

26. CITU: A Peptide and Decarboxylative Coupling Reagent 

CITU_graphical abstract

J. N. deGruyter, L. R. Malins, L. Wimmer, K. J. Clay, J. Lopez-Ogalla, T. Qin, J. Cornella, Z. Liu, G. Che, D. Bao, J. M. Stevens, J. X. Qiao, M. P. Allen, M. A. Poss, P. S. Baran, Org. Lett. 2017, 19, 6196–6199.

25. Residue-Specific Peptide Modification

Residue Specific modifications_Biochemistry_grpahical abstract

J. N. deGruyter, L. R. Malins, P. S. Baran, Biochemistry 2017, 56, 3863–3873.

24. Decarboxylative Alkynylation

Alkyne TOC

J. M. Smith, T. Qin, R. R. Merchant, J. T. Edwards, L. R. Malins, Z. Liu, G. Che, Z. Shen, S. A. Shaw, M. D. Eastgate, P. S. Baran, Angew. Chem. Int. Ed. 2017, 56, 11906–11910.

23. Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products


L. R. Malins, J. N. deGruyter, K. J. Robbins, P. M. Scola, M. D. Eastgate, M. R. Ghadiri, P. S. Baran, J. Am. Chem. Soc. 2017, 139, 5233–5241.

22. Decarboxylative Alkenylation

TOC alkenylation

J. T. Edwards, R. R. Merchant, K. S. McClymont, K. W. Knouse, T. Qin, L. R. Malins, B. Vokits, S. A. Shaw, D.-H. Bao, F.-L. Wei, T. Zhou, M. D. Eastgate, P. S. Baran, Nature 2017, 545, 213.

21. Transition Metal-Promoted Arylation: An Emerging Strategy for Protein Bioconjugation

AJC - Graphical abstract Transition-metal mediated protein arylation

L. R. Malins, Aust. J. Chem. 2017, 69, 1360–1364.

20. Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity

strain-release 2 TOC

J. M. Lopchuk, K. Fjelbye, Y. Kawamata, L. R. Malins, C.-M. Pan, R. Gianatassio, J. Wang, L. Prieto, J. Bradow, T. A. Brandt, M. R. Collins, J. Elleraas, J. Ewanicki, W. Farrell, O. O. Fadeyi, G. M. Gallego, J. J. Mousseau, R. Oliver, N. W. Sach, J. K. Smith, J. E. Spangler, H. Zhu, J. Zhu, P. S. Baran, J. Am. Chem. Soc. 2017, 139, 3209–3226.

19. Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms

Decarboxylative Giese TOC

T. Qin, L. R. Malins, J. T. Edwards, R. R. Merchant, A. J. E. Novak, J. Z. Zhong, R. B. Mills, M. Yan, C. Yuan, M. D. Eastgate, P. S. Baran, Angew. Chem. Int. Ed. 2017, 56, 260–265.

18. One-Pot Ligation–Oxidative Deselenization at Selenocysteine and Selenocystine

One-Pot Ligation-oxid deselenization TOC

N. J. Mitchell, S. S. Kulkarni, L. R. Malins, S. Wang, R. J. Payne, Chem—Eur. J. 2017, 23, 946–952.

17. A General Alkyl-Alkyl Cross-Coupling Enabled by Redox- Active Esters and Alkylzinc Reagents

Science paper TOC

T. Qin, J. Cornella, C. Li, L. R. Malins, J. T. Edwards, S. Kawamura, B. D. Maxwell, M. D. Eastgate, P. S. Baran, Science, 2016, 352, 801–805.

16. Strain-Release Amination

TOC strain release amination part1 Science

R. Gianatassio, J. M. Lopchuk, J. Wang, C.-M. Pan, L. R. Malins, L. Prieto, T. A. Brandt, M. R. Collins, G. M. Gallego, N. W. Sach, J. E. Spangler, H. Zhu, J. Zhu, P. S. Baran, Science, 2016, 351, 241–246.

15. Single Addition of an Allylamine Monomer Enables Access to End-Functionalized RAFT Polymers for Native Chemical Ligation

TOC RAFT polymer NCL

N. Isahak, G. Gody, L. R. Malins, N. J. Mitchell, R. J. Payne, S. Perrier, Chem. Commun. 2016, 52, 12952–12955.

14. Oxidative Deselenization of Selenocysteine: Applications for Programmed Ligation at Serine

Graphical Abstract Oxidative Deselenization

L. R. Malins, N. J. Mitchell, S. McGowan, R. J. Payne, Angew. Chem. Int. Ed. 2015, 54, 12716–12721.

13. Rapid Additive-Free Selenocystine-Selenoester Peptide Ligation


N. J. Mitchell, L. R. Malins, X. Liu, R. E. Thompson, B. Chan, L. Radom, R. J. Payne, J. Am. Chem. Soc. 2015, 137, 14011–14014.

12. Thiazolidine-Protected β-Thiol Asparagine: Applications in One-Pot Ligation-Desulfurization Chemistry

Beta-thiol Asn TOC

J. Sayers, R. E. Thompson, K. J. Perry, L. R. Malins, R. J. Payne, Org. Lett. 2015, 17, 4902–4905.

11. Synthesis of β-Thiol Phenylalanine for Applications in One-Pot Ligation-Desulfurization Chemistry

B-thiol Phe TFET One-pot TOC

L. R. Malins, A. M. Giltrap, L. J. Dowman, R. J. Payne, Org. Lett. 2015, 17, 2070–2073.

10. Synthetic Amino Acids for Applications in Peptide Ligation- Desulfurization Chemistry

Aust J Chem graphical abstract thiol AAs

L. R. Malins, R. J. Payne, Aust. J. Chem. 2015, 68, 521–537.

9. Recent Extensions to Native Chemical Ligation for the Chemical Synthesis of Peptides and Proteins

Graphical Abstract Curr Opin_ligation_TOC

L. R. Malins, R. J. Payne, Curr. Opin. Chem. Biol. 2014, 22, 70–78.

8. Site-Selective Solid-Phase Synthesis of a CCR5 Sulfopeptide Library to Interrogate HIV Binding and Entry

CCR5 Sulfopeptide TOC

X. Liu, L. R. Malins, M. Roche, R. Duncan, M. Garcia, D. Anderson, M. J. Stone, P. R. Gorry, R. J. Payne, ACS Chem. Biol. 2014, 9, 2074–2081.

7. Chemoselective Sulfenylation and Peptide Ligation at Tryptophan

Chemical Science 2-thiol Trp Abstract Graphic

L. R. Malins, K. M. Cergol, R. J. Payne, Chem. Sci. 2014, 5, 260–266.

6. One-Pot Peptide Ligation-Desulfurization at Glutamate

Glu lig-desulf OL TOC

K. M. Cergol, R. E. Thompson, L. R. Malins, R. J. Payne, Org. Lett. 2014, 16, 290–293.

5. Peptide Ligation Chemistry at Selenol Amino Acids


L. R. Malins, N. J. Mitchell, R. J. Payne, J. Pept. Sci. 2014, 20, 64–77.

4. Peptide Ligation-Desulfurization Chemistry at Arginine

Arg TOC screenshot_edit

L. R. Malins, K. M. Cergol, R. J. Payne, ChemBioChem 2013, 14, 559–563.

3. Synthesis and Utility of β-Selenol-Phenylalanine for Native Chemical Ligation-Deselenization Chemistry

B-selenol Phe TOC OL2012

L. R. Malins, R. J. Payne, Org. Lett. 2012, 14, 3142–3145.

2. Self-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam3CysSer


B. L. Wilkinson, S. Day, L. R. Malins, V. Apostolopoulos, R. J. Payne, Angew. Chem. Int. Ed. 2011, 50, 1635–1639.

1. Synthesis of MUC1- Lipopeptide Chimeras

Chem Comm MUC1 2010 TOC

B. L. Wilkinson, L. R. Malins, C. K. Y. Chun, R. J. Payne, Chem. Commun. 2010, 46, 6249–6251.