64. Retrofitting HPLC Hardware for Affordable and Accessible Flow-Based Peptide Synthesis
A. M. White, D. A. Williamson, C. L. Gare, F. C. Attard, A. M. Kidston, L. R. Malins, Aust. J. Chem. 2025, DOI: 10.1071/CH25155
[Selected Editor’s Choice]
63. Dibromocarbene Addition to Bicyclo[1.1.0]butanes: A Facile Route to Substituted Bicyclo[1.1.1]pentanes
F. C. Attard, A. Slobodianyk, R. Bychek, Y. Panasiuk, P. Neigenfind, L. Massaro, V. V. Levterov, P. S. Baran, P. K. Mykhailiuk, L. R. Malins, Proc. Natl. Acad. Sci. U. S. A. 2025, 122, e2524130122.
First published as a pre-print: ChemRxiv 2025, doi: 10.26434/chemrxiv-2024-rr5p5-v2
62. Combining Bioactive Cell-Penetrating Peptides and Vemurafenib to Produce Peptide−Drug Conjugates with Activity Against Drug-Resistant Melanoma Cells
I. R. Palombi, A. M. White, Y. Koda, D. J. Craik, S. T. Henriques, N. Lawrence, L. R. Malins, J. Med. Chem. 2025, doi: 10.1021/acs.jmedchem.5c02367.
61. Insights into Platelet Factor 4-Derived Peptide Macrocycles; The Mechanistic Basis of their Rapid and Selective Antiplasmodial Actions
D. W. Xu, K. Raven, S. R. Woodcock, B. Munro, I. R. Palombi, C. L. Gare, A. M. White, L. R. Malins, N. Lawrence, B. J. McMorran, Cell. Mol. Life Sci. 2025, 82, 228.
https://link.springer.com/article/10.1007/s00018-025-05757-y
60. Cell-Penetrating Cyclic and Disulfide-Rich Peptides Are Privileged Molecular Scaffolds for Intracellular Targeting
S. T. Henriques, N. Lawrence, M.-W. Kan, L. R. Malins, D. J. Craik, Biochemistry 2025, 64, 1437.
59. Harnessing the power of peptides: advances and collaborations in biochemistry
L. Coassolo, K. J. Svensson, C. L. Gare, A. M. White, L. R. Malins, A. B. Smith, J. R. Chekan, Trends Biochem. Sci. 2025, 50, 458.
58. From lead to market: chemical approaches to transform peptides into therapeutics
C. L. Gare, A. M. White, L. R. Malins, Trends Biochem. Sci. 2025, 50, 467.
57. Synthesis and Investigation of Peptide–Drug Conjugates Comprising Camptothecin and a Human Protein-Derived Cell-Penetrating Peptide
I. R. Palombi, A. M. White, Y. Koda, D. J. Craik, N. Lawrence, L. R. Malins, Chem. Biol. Drug Des. 2025, 105, e70051.
56. Exploring the Utility of Cell-Penetrating Peptides as Vehicles for the Delivery of Distinct Antimalarial Drug Cargoes
C. L. Gare, I. R. Palombi, A. M. White, M. Chavchich, M. D. Epstein, A. Lock, V. M. Avery, D. J. Craik, B. J. McMorran, N. Lawrence, L. R. Malins, ChemMedChem 2025, 20, e202400637.
[Highlighted in Chemistry Views]
55. Radical Reactions for the Construction and Transformation of Complex Molecules
M. Inoue, L. R. Malins, H. Renata, Org. Lett. 2024, 26, 7775.
[Editorial – Special Issue on Radical Reactions]
54. Accessing Therapeutically-Relevant Multifunctional Antisense Oligonucleotide Conjugates Using Native Chemical Ligation
D. Engelhardt, P. Nordberg, L. Knerr, L. R. Malins, Angew. Chem. Int. Ed. 2024, 63, e202409440.
53. Enhancing the Intrinsic Antiplasmodial Activity and Improving the Stability and Selectivity of a Tunable Peptide Scaffold Derived from Human Platelet Factor 4
N. Lawrence, T. N. G. Handley, S. J. de Veer, M. D. Harding, A. Andraszek, L. Hall, K. D. Raven, S. Duffy, V. M. Avery, D. J. Craik, L. R. Malins, B. J. McMorran, ACS Infectious Diseases 2024, 10, 2899.
52. Total Synthesis of a Peptide Diatom Sex Pheromone Bearing a Sulfated Aspartic Acid
A. M. White, B. D. Schwartz, M. G. Gardiner, L. R. Malins, Org. Lett. 2024, 26, 6803.
51. Structural Characterization of Enzymatic Interactions with Functional Nicotinamide Cofactor Biomimetics
R. A. Rocha, L. A. Wilson, B. D. Schwartz, A. C. Warden, L. W. Guddat, R. E. Speight, L. Malins, G. Schenk, C. Scott, Catalysts 2024, 14, 399. https://doi.org/10.3390/catal14070399
50. Electrochemical Modification of Polypeptides at Selenocysteine
A. S. Mackay, J. W. C. Maxwell, M. J. Bedding, S. S. Kulkarni, S. A. Byrne, L. Kambanis, M. V. Popescu, R. S. Paton, L. R. Malins, A. S. Ashhurst, L. Corcilius, R. J. Payne, Angew. Chem. Int. Ed. 2023, 62, e202313037.
49. Complex Inhibitory Mechanism of Glycomimetics with Heparanase
C. Whitefield, Y. Vo, B. D. Schwartz, C. Hepburn, F. H. Ahmed, H. Onagi, M. G. Banwell, K. Nelms, L. R. Malins, C. J. Jackson, Biochemistry 2023, doi: 10.1021/acs.biochem.3c00038
48. Development of Antiplasmodial Peptide–Drug Conjugates Using a Human Protein-Derived Cell-Penetrating Peptide with Selectivity for Infected Cells
I. R. Palombi, N. Lawrence, A. M. White, C. L. Gare, D. J. Craik, B. J. McMorran, L. R. Malins, Bioconjugate Chem. 2023, doi: 10.1021/acs.bioconjchem.3c00147
47. Fine-Tuning Electroauxiliary-Mediated Peptide Modifications Using Second-Generation Electroactive Amino Acids
D. Karipal Padinjare Veedu, L. A. Connal, L. R. Malins, Org. Lett. 2023, doi: 10.1021/acs.orglett.3c00988
46. Amino Acid Sulfinate Salts as Alkyl Radical Precursors
J. M. Hammond, M. G. Gardiner, L. R. Malins, Org. Lett. 2023, doi: 10.1021/acs.orglett.3c01112
45. Tunable Electrochemical Peptide Modifications: Unlocking New Levels of Orthogonality for Side-Chain Functionalization
D. Karipal Padinjare Veedu, L. A. Connal, L. R. Malins, Angew. Chem. Int. Ed. 2023, 62, e202215470, doi: 10.1002/anie.202215470
44. Accessing Diverse Cross-Benzoin and α‐Siloxy Ketone Products via Acyl Substitution Chemistry
C. N. Larcombe, L. R. Malins, J. Org. Chem. 2022, doi: 10.1021/acs.joc.2c00801
[Featured on Organic Chemistry Portal]
43. Peptide Macrocyclisation via Late-Stage Reductive Amination
H. J. Bell, L. R. Malins, Org. Biomol. Chem. 2022, doi: 10.1039/D2OB00782G
[Featured in Org. Chem. Highlights]
42. Synthesis of Amino Acid α-Thioethers and Late-Stage Incorporation into Peptides
K. D. Milewska, L. R. Malins, Org. Lett. 2022, doi: 10.1021/acs.orglett.2c01297
41. Synthesis of Peptide N-Acylpyrroles via Anodically Generated N,O-Acetals
Y. Lin, L. R. Malins, Synthesis 2022, doi: 10.1055/s-0041-1737411
40. Umpolung Strategies for the Functionalization of Peptides and Proteins
A. M. White, I. R. Palombi, L. R. Malins, Chem. Sci. 2022, doi: 10.1039/D1SC06133J
39. Investigating Bicyclobutane–Triazolinedione Cycloadditions as a Tool for Peptide Modification
B. D. Schwartz, A. P. Smyth, P. E. Nashar, M. G. Gardiner, L. R. Malins, Org. Lett. 2022, doi: 10.1021/acs.orglett.1c04071
38. Electrochemistry for the Chemoselective Modification of Peptides and Proteins
A. S. Mackay, R. J. Payne, L. R. Malins, J. Am. Chem. Soc. 2021, doi: 10.1021/jacs.1c11185
37. Polymer End Group Control through a Decarboxylative Cobalt-Mediated Radical Polymerization: New Avenues for Synthesizing Peptide, Protein, and Nanomaterial Conjugates
M. Ayurini, P. G. Chandler, P. D. O’Leary, R. Wang, D. Rudd, K. D. Milewska, L. R. Malins, A. M. Buckle, J. F. Hooper, JACS Au 2021, doi: 10.1021/jacsau.1c00453
36. Organometallic Reagents Primed for Peptide Modification
C. Elgindy, L. R. Malins, Chem Catalysis 2021, 1, 758–760. [Preview Article]
35. An Electrochemical Approach to Designer Peptide α-Amides Inspired by α-Amidating Monooxygenase Enzymes
Y. Lin, L. R. Malins, J. Am. Chem. Soc. 2021, doi: 10.1021/jacs.1c05718
34. A Rapid and Mild Sulfation Strategy Reveals Conformational Preferences in Therapeutically Relevant Sulfated Xylooligosaccharides
Y. Vo, B. D. Schwartz, H. Onagi, J. S. Ward, M. G. Gardiner, M. G. Banwell, K. Nelms, L. R. Malins, Chem. Eur. J. 2021, doi: 10.1002/chem.202100527
33. Total Synthesis of Biseokeaniamides A-C and Late-Stage Electrochemically-Enabled Peptide Analogue Synthesis
Y. Lin, L. R. Malins, Chem. Sci. 2020, 11, 10752–10758.
32. Structurally Diverse Acyl Bicyclobutanes: Valuable Strained Electrophiles
B. D. Schwartz, M. Y. Zhang, R. H. Attard, M. G. Gardiner, L. R. Malins, Chem. Eur. J. 2020, 26, 2808–2812.
31. Late-Stage Functionalization of Histidine in Unprotected Peptides
A. F. M. Noisier, M. J. Johansson, L. Knerr, M. A. Hayes, W. J. Drury III, E. Valeur, L. R. Malins, R. Gopalakrishnan, Angew. Chem. Int. Ed. 2019, 58, 19096–19102.
30. Total Synthesis of Suillusin
M. Y. Zhang, L. R. Malins, J. S. Ward, R. A. Barrow, Org. Lett. 2018, 20, 7304–7307.
29. Hitting the Sweet Spot
Nature Chemistry News & Views Highlight
L. R. Malins, Nature Chem. 2018, 10, 578–580.
28. Peptide Modification and Cyclization via Transition-Metal Catalysis
L. R. Malins, Curr. Opin. Chem. Biol. 2018, 46, 25–32.
27. Decarboxylative Couplings as Versatile Tools for Late-Stage Peptide Modifications
L. R. Malins, Peptide Science, 2018, doi: 10.1002/pep2.24049
26. CITU: A Peptide and Decarboxylative Coupling Reagent
J. N. deGruyter, L. R. Malins, L. Wimmer, K. J. Clay, J. Lopez-Ogalla, T. Qin, J. Cornella, Z. Liu, G. Che, D. Bao, J. M. Stevens, J. X. Qiao, M. P. Allen, M. A. Poss, P. S. Baran, Org. Lett. 2017, 19, 6196–6199.
25. Residue-Specific Peptide Modification
J. N. deGruyter, L. R. Malins, P. S. Baran, Biochemistry 2017, 56, 3863–3873.
24. Decarboxylative Alkynylation
J. M. Smith, T. Qin, R. R. Merchant, J. T. Edwards, L. R. Malins, Z. Liu, G. Che, Z. Shen, S. A. Shaw, M. D. Eastgate, P. S. Baran, Angew. Chem. Int. Ed. 2017, 56, 11906–11910.
23. Peptide Macrocyclization Inspired by Non-Ribosomal Imine Natural Products
L. R. Malins, J. N. deGruyter, K. J. Robbins, P. M. Scola, M. D. Eastgate, M. R. Ghadiri, P. S. Baran, J. Am. Chem. Soc. 2017, 139, 5233–5241.
22. Decarboxylative Alkenylation
J. T. Edwards, R. R. Merchant, K. S. McClymont, K. W. Knouse, T. Qin, L. R. Malins, B. Vokits, S. A. Shaw, D.-H. Bao, F.-L. Wei, T. Zhou, M. D. Eastgate, P. S. Baran, Nature 2017, 545, 213.
21. Transition Metal-Promoted Arylation: An Emerging Strategy for Protein Bioconjugation
L. R. Malins, Aust. J. Chem. 2017, 69, 1360–1364.
20. Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity
J. M. Lopchuk, K. Fjelbye, Y. Kawamata, L. R. Malins, C.-M. Pan, R. Gianatassio, J. Wang, L. Prieto, J. Bradow, T. A. Brandt, M. R. Collins, J. Elleraas, J. Ewanicki, W. Farrell, O. O. Fadeyi, G. M. Gallego, J. J. Mousseau, R. Oliver, N. W. Sach, J. K. Smith, J. E. Spangler, H. Zhu, J. Zhu, P. S. Baran, J. Am. Chem. Soc. 2017, 139, 3209–3226.
19. Nickel-Catalyzed Barton Decarboxylation and Giese Reactions: A Practical Take on Classic Transforms
T. Qin, L. R. Malins, J. T. Edwards, R. R. Merchant, A. J. E. Novak, J. Z. Zhong, R. B. Mills, M. Yan, C. Yuan, M. D. Eastgate, P. S. Baran, Angew. Chem. Int. Ed. 2017, 56, 260–265.
18. One-Pot Ligation–Oxidative Deselenization at Selenocysteine and Selenocystine
N. J. Mitchell, S. S. Kulkarni, L. R. Malins, S. Wang, R. J. Payne, Chem—Eur. J. 2017, 23, 946–952.
17. A General Alkyl-Alkyl Cross-Coupling Enabled by Redox- Active Esters and Alkylzinc Reagents
T. Qin, J. Cornella, C. Li, L. R. Malins, J. T. Edwards, S. Kawamura, B. D. Maxwell, M. D. Eastgate, P. S. Baran, Science, 2016, 352, 801–805.
16. Strain-Release Amination
R. Gianatassio, J. M. Lopchuk, J. Wang, C.-M. Pan, L. R. Malins, L. Prieto, T. A. Brandt, M. R. Collins, G. M. Gallego, N. W. Sach, J. E. Spangler, H. Zhu, J. Zhu, P. S. Baran, Science, 2016, 351, 241–246.
15. Single Addition of an Allylamine Monomer Enables Access to End-Functionalized RAFT Polymers for Native Chemical Ligation
N. Isahak, G. Gody, L. R. Malins, N. J. Mitchell, R. J. Payne, S. Perrier, Chem. Commun. 2016, 52, 12952–12955.
14. Oxidative Deselenization of Selenocysteine: Applications for Programmed Ligation at Serine
L. R. Malins, N. J. Mitchell, S. McGowan, R. J. Payne, Angew. Chem. Int. Ed. 2015, 54, 12716–12721.
13. Rapid Additive-Free Selenocystine-Selenoester Peptide Ligation
N. J. Mitchell, L. R. Malins, X. Liu, R. E. Thompson, B. Chan, L. Radom, R. J. Payne, J. Am. Chem. Soc. 2015, 137, 14011–14014.
12. Thiazolidine-Protected β-Thiol Asparagine: Applications in One-Pot Ligation-Desulfurization Chemistry
J. Sayers, R. E. Thompson, K. J. Perry, L. R. Malins, R. J. Payne, Org. Lett. 2015, 17, 4902–4905.
11. Synthesis of β-Thiol Phenylalanine for Applications in One-Pot Ligation-Desulfurization Chemistry
L. R. Malins, A. M. Giltrap, L. J. Dowman, R. J. Payne, Org. Lett. 2015, 17, 2070–2073.
10. Synthetic Amino Acids for Applications in Peptide Ligation- Desulfurization Chemistry
L. R. Malins, R. J. Payne, Aust. J. Chem. 2015, 68, 521–537.
9. Recent Extensions to Native Chemical Ligation for the Chemical Synthesis of Peptides and Proteins
L. R. Malins, R. J. Payne, Curr. Opin. Chem. Biol. 2014, 22, 70–78.
8. Site-Selective Solid-Phase Synthesis of a CCR5 Sulfopeptide Library to Interrogate HIV Binding and Entry
X. Liu, L. R. Malins, M. Roche, R. Duncan, M. Garcia, D. Anderson, M. J. Stone, P. R. Gorry, R. J. Payne, ACS Chem. Biol. 2014, 9, 2074–2081.
7. Chemoselective Sulfenylation and Peptide Ligation at Tryptophan
L. R. Malins, K. M. Cergol, R. J. Payne, Chem. Sci. 2014, 5, 260–266.
6. One-Pot Peptide Ligation-Desulfurization at Glutamate
K. M. Cergol, R. E. Thompson, L. R. Malins, R. J. Payne, Org. Lett. 2014, 16, 290–293.
5. Peptide Ligation Chemistry at Selenol Amino Acids
L. R. Malins, N. J. Mitchell, R. J. Payne, J. Pept. Sci. 2014, 20, 64–77.
4. Peptide Ligation-Desulfurization Chemistry at Arginine
L. R. Malins, K. M. Cergol, R. J. Payne, ChemBioChem 2013, 14, 559–563.
3. Synthesis and Utility of β-Selenol-Phenylalanine for Native Chemical Ligation-Deselenization Chemistry
L. R. Malins, R. J. Payne, Org. Lett. 2012, 14, 3142–3145.
2. Self-Adjuvanting Multicomponent Cancer Vaccine Candidates Combining Per-Glycosylated MUC1 Glycopeptides and the Toll-like Receptor 2 Agonist Pam3CysSer
B. L. Wilkinson, S. Day, L. R. Malins, V. Apostolopoulos, R. J. Payne, Angew. Chem. Int. Ed. 2011, 50, 1635–1639.
1. Synthesis of MUC1- Lipopeptide Chimeras
B. L. Wilkinson, L. R. Malins, C. K. Y. Chun, R. J. Payne, Chem. Commun. 2010, 46, 6249–6251.